Ergotism unresponsive to multiple therapeutic modalities, including sodium nitroprusside, resulting in limb loss

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Ergotism unresponsive to multiple therapeutic modalities, including sodium nitroprusside, resulting in limb loss.

Unlike epidemics in past centuries, patients suffering from peripheral vascular ischemia related to ergotism now rarely lose a limb because of vasodilator therapies. We report a patient with ischemia from ergotamine tartrate who failed to recover with medical therapy, resulting in limb amputation.

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Therapeutic Interchange of Clevidipine For Sodium Nitroprusside in Cardiac Surgery.

BACKGROUND Generic price inflation has resulted in rising acquisition costs for sodium nitroprusside (SNP), an agent historically described as the drug of choice for the treatment of perioperative hypertension in cardiac surgery. PURPOSE To describe the implementation and cost avoidance achieved by utilizing clevidipine as an alternative to SNP in cardiac surgery patients at a 520-bed communi...

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Nonconventional therapeutic modalities in refractory angina pectoris

    Abstract   Despite sophisticated conventional medical treatment and the continued development   and improvement of coronary revascularization modalities in recent years, a significant   number of patients still suffer from refractory angina pectoris and cannot be successfully   managed. Advances in therapeutic options have led to an increase in the average of life   expectancy even in such ...

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Sodium Nitroprusside Injection

Except when used briefly or at low (< 2 mcg/kg/min) infus ion rates , sodium nitropruss ide gives rise to important quantities of cyanide ion, which can reach toxic, potentially lethal levels (see WARNINGS). The usual dose rate is 0.5 to 10 mcg/kg/min, but infus ion at the maximum dose rate should never las t more than 10 minutes . If blood pressure has not been adequately controlled after 10 m...

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0354. Effects of sodium nitroprusside in addition to therapeutic hypothermia after experimental cardiac arrest

Methods We studied 8 anesthetized, invasively monitored and mechanically ventilated domestic pigs, randomized into two groups (n=4): TH without or with SNP. After 3 min of untreated ventricular fibrillation, cardiopulmonary resuscitation (CPR) was started in all animals and continued until return of spontaneous circulation (ROSC); defibrillation was performed 3 minutes after the start of CPR. H...

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ژورنال

عنوان ژورنال: Clinical Toxicology

سال: 2008

ISSN: 1556-3650,1556-9519

DOI: 10.1080/15563650701664426